2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-W748582
    Clozapine N-oxide-d8 98%
    Clozapine N-oxide-d8 is the deuterium labeled Clozapine N-oxide (HY-17366). Clozapine N-oxide is a major metabolite of Clozapine and a human muscarinic designer receptors (DREADDs) agonist. Clozapine N-oxide activates the DREADD receptor hM3Dq and hM4Di. Clozapine N-oxide can't cross the blood-brain barrier. Clozapine is a potent dopamine antagonist and also a potent and selective muscarinic M4 receptor (EC50=11 nM) agonist.
    Clozapine N-oxide-d8
  • HY-W749797
    Nitrazolam 28910-99-8 99.9%
    Nitrazolam is a benzodiazepine compound, that may exhibit CNS depressant properties as traditional benzodiazepines, including sedation, hypnosis, anxiolysis, and anticonvulsant effects, by acting on GABA receptors.
    Nitrazolam
  • HY-W749844
    Homoeriodictyol chalcone 52218-19-6 98%
    Homoeriodictyol chalcone (2',4,4',6'-Tetrahydroxy-3-methoxychalcone; 3-Methoxy-2',4',6',4-tetrahydroxychalcone) is a non-selective antioxidant radical scavenger that neutralizes reactive oxygen species (ROS). Homoeriodictyol chalcone is promising for research of neurodegenerative diseases (e.g., Alzheimer’s), inflammatory disorders, and cancers.
    Homoeriodictyol chalcone
  • HY-W750153
    Propoxur-d7 2140327-65-5 98%
    Propoxur-d7 is the deuterium labeled Propoxur. Propoxur is a reversible, competitive, orally active AChE inhibitor that can cross the blood-brain barrier. Propoxur inhibits AChE activity to induce neurotoxicity, while promoting MMP-2 expression and enhancing tumor cell migration and invasion by inducing intracellular ROS generation and activating the ERK/Nrf2 signaling pathway. On the one hand, Propoxur inhibits AChE, leading to acetylcholine accumulation and causing neurological dysfunction; on the other hand, it promotes Nrf2 nuclear translocation through ROS-dependent ERK1/2 phosphorylation, and upregulates MMP-2 and other invasion-related proteins. Propoxur is also a carbamate insecticide used to combat turf, forestry, and household pests.
    Propoxur-d7
  • HY-W750404
    (-)-Carvone-d4 98%
    (-)-Carvone-d4 is the deuterium labeled (-)-Carvone (HY-W017423). (-)-Carvone is an insect neurotoxin and a irreversible acetylcholinesterase (AChE) inhibitor. (-)-Carvone can be used as a bird repellent, inhibits larval growth, decreases pupatation rate, and increases mortality of larvae.
    (-)-Carvone-d4
  • HY-W750970
    2-Acetoxyacorenone 185154-95-4 98%
    2-Acetoxyacorenone (compound 8) is a sesquiterpenoid, which can be isolated from the rhizome of Acorus tatarinowii. 2-Acetoxyacorenone has potent AChE and β-BACE1 inhibitory activity and can be used in the study of Alzheimer's disease.
    2-Acetoxyacorenone
  • HY-W751156
    O-Phospho-L-serine-13C3 2734707-32-3 98%
    O-Phospho-L-serine-13C3 (L-Serine O-phosphate-13C3) is the 13C-labeled O-Phospho-L-serine (HY-15129). O-Phospho-L-serine is the immediate precursor to L-cystein in the serine synthesis pathway, and an agonist at the group III mGluR receptors (mGluR4, mGluR6, mGluR7, and mGluR8); O-Phospho-L-serine also acts as a weak antagonist for mGluR1 and a potent antagonist for mGluR2.
    O-Phospho-L-serine-13C3
  • HY-W751350
    Cyclobenzaprine-d6 1261396-60-4 98%
    Cyclobenzaprine-d6 is the deuterium labeled Cyclobenzaprine. Cyclobenzaprine (MK130) hydrochloride is an orally active 5-HT2 receptor antagonist. Cyclobenzaprine hydrochloride acts centrally, providing skeletal muscle relaxation, alleviating muscle spasms, and reducing pain. Cyclobenzaprine hydrochloride also possesses antiparasitic activity. Cyclobenzaprine hydrochloride holds promise for research in the fields of acute, painful skeletal muscle disorders and infectious diseases.
    Cyclobenzaprine-d6
  • HY-W751669
    9-Fluorenol-d9 98%
    9-Fluorenol-d9 (9-Hydroxyfluorene-d9) is the deuterium labeled 9-Fluorenol (HY-W016388). 9-Fluorenol (9-Hydroxyfluorene; compound 3) is a dopamine (DAT) inhibitor with IC50 value of 9 μM. 9-Fluorenol is a major metabolite of compound developed as a wake promoting agent. 9-Fluorenol shows wake promotion activity in vivo.
    9-Fluorenol-d9
  • HY-W751734
    HU 433 1220887-84-2 98%
    HU 433 is a synthetic cannabinoid CB2 receptor agonist and is the enantiomer of HU 308 (HY-161510). HU 433 exerts its anti-inflammatory and neuroprotective effects by binding to CB2 receptors. HU 433 can be used in the study of neuroinflammation and retinal diseases.
    HU 433
  • HY-W751750
    Urethane-13C,15N 98%
    Urethane-13C,15N (Ethyl carbamate-13C,15N) is the 13C- and 15N-labeled Urethane (HY-B1207). Urethane (Ethyl carbamate), the ethyl ester of carbamic acid, is a byproduct of fermentation found in various food products. Urethane has the ability to suppress bacterial, protozoal, sea urchin egg, and plant tissue growth in vitro.
    Urethane-13C,15N
  • HY-W752012
    Adapalene-13C6 98%
    Adapalene-13C6 (CD271-13C6) is the 13C-labeled Adapalene (HY-B0091). Adapalene (CD271), a third-generation synthetic retinoid, is widely used for the research of acne. Adapalene is a potent RAR agonist, with AC50s of 2.3 nM, 9.3 nM, and 22 nM for RARβ, RARγ, RARα, respectively. Adapalene also inhibits the enzymatic activity of GOT1 in a non-competitive manner. Adapalene exhibits anti-tumor activity.
    Adapalene-13C6
  • HY-W752907
    Glufosinate-d8 98%
    Glufosinate-d8 is the deuterium labeled Glufosinate (HY-W019870A). Glufosinate, a phosphinic acid analogue of glutamic acid, is a herbicide which is converted by plant cells into PT (L-phosphinothricin). Glufosinate exerts neurotoxic activity.
    Glufosinate-d8
  • HY-W753326
    N-Isopropyl hexylone hydrochloride 27912-43-2 98%
    N-Isopropyl hexylone hydrochloride is a drug derivative.
    N-Isopropyl hexylone hydrochloride
  • HY-W753473
    4-Ethylphenol-d9 2241872-74-0 98%
    4-Ethylphenol-d9 is the deuterium labeled 4-Ethylphenol (HY-W012836). 4-Ethylphenol is a volatile phenolic compound associated with off-odour in wine. 4-Ethylphenol is a phenolic compound that can be synthesized by intestinal flora. 4-Ethylphenol will be converted to 4-ethylphenyl sulfate (HY-W674241) by Lactobacillus plantarum.
    4-Ethylphenol-d9
  • HY-W753485
    Profenofos-d3 2140327-42-8 98%
    Profenofos-d3 is the deuterium labeled Profenofos (HY-B0832). Profenofos is an insecticida used on field crops, vegetables, and fruit crops. Profenofos is an acetylcholinesterase (AChE) inhibitor, with neurotoxicity.
    Profenofos-d3
  • HY-W753724
    N-Ethyl 2C-B hydrochloride 155638-84-9 98%
    N-Ethyl 2C-B hydrochloride is a phenethylamine with psychoactive properties.
    N-Ethyl 2C-B hydrochloride
  • HY-W754114
    Nalmefene Sulfate-d3 98%
    Nalmefene Sulfate-d3 is the deuterium labeled Nalmefene (HY-107744). Nalmefene is a BBB-penetrable opioid receptor modulator. Nalmefene is an antagonist of MOR and DOR, and a partial agonist of KOR. Nalmefene has anti-inflammatory and neuroprotective activities. Nalmefene can be used in the research of reducing alcohol-dependent disorders.
    Nalmefene Sulfate-d3
  • HY-W754293
    Deanol pidolate 23513-72-6 98%
    Deanol pidolate (V0191; DMAE pidolate) is an orally active pro-cholinergic agent that improves cognitive symptoms by increasing the release of acetylcholine (Ach) and avoids the typical side effects of cholinesterase inhibitors. Deanol pidolate can alleviate the harmful effects of scopolamine on long-term memory and restore to baseline levels more quickly. Deanol pidolate can be used in research on Alzheimer's disease.
    Deanol pidolate
  • HY-W754627
    Clazolam 7492-29-7 98%
    Clazolam (Isoquinazepon; SAH-1123) is a GABA Receptor modulator. Clazolam can be used in research on neurological diseases.
    Clazolam
Cat. No. Product Name / Synonyms Application Reactivity